Alternating between Madeleine the young woman and Madeleine disguised as César, players are plunged into a thriller where political scheming and ancestral prophecies are intertwined. The game begins as an initiatory adventure in the footsteps of her father, the prophet and astrologer, before creating all the suspense of a detective novel: from one murder to another, players make their way through a test-riddled forensic investigation.
Following in the same vein as The Secrets of Da Vinci - The Forbidden Manuscript©, Nostradamus - The Last Prophecy is an historical adventure game in which players have to solve a series of riddles and puzzles inspired by the works of Nostradamus, taking them through the worlds of astrology, medicine and medicinal plants.
Though the game does not offer two fundamentally different paths, "transforming" the main character gives players a unique alternative by allowing them to assume another identity, change sex (their appearance in any case) and use it to their advantage when interacting with other characters.